from the north: A1 exit Valdichiana - Torrita di Siena - Pienza - San Quirico d'Orcia - Bagno Vignoni (32 km).

From the south: A1 exit Chiusi-Chianciano - Chiusi - Chianciano Terme - Pienza - San Quirico d'Orcia - Bagno Vignoni (37 km).

From the coast: E80/SS1 - exit Roselle Grosseto - Paganico - turn right towards Amiata - Castel del Piano - turn left for Sant'Angelo in Colle - Montalcino - San Quirico d'Orcia - Bagno Vignoni (73 km).

From Florence: take the raccordo (main road) Siena-Firenze, in Siena take the SS2 (CASSIA) SUD (southbound) until the exit for Bagno Vignoni.